World number one Jannik Sinner opens the match at Arthur Ashe Stadium against Alex Michelsen from the USA.
Italian Sinner is aiming for his second Grand Slam title after winning the Australian Open, but has endured a turbulent time in the run-up to the tournament after it was revealed in March that he tested positive for a banned substance.
Sinner is followed by the top seed in the women’s singles, Iga Swiatek, who is the clear favorite against the Japanese qualifier Ena Shibahara.
Two-time US Open champion Naomi Osaka of Japan opens the evening session against Karolina Muchova of the Czech Republic.
The final match is between Carlos Alcaraz and the Dutchman Botic van de Zandschlup.
Elsewhere, French Open and Wimbledon finalist Jasmine Paolini will face former world number one Karolina Pliskova, followed by an all-American contest between Emma Raducanu’s conqueror Sofia Kenin and sixth seed Jessica Peluga.
The fifth seeded men’s player Daniil Medvedev will face Hungarian Fabian Marozsan in the evening session.
There’s also plenty of double action with plenty of British interest.
Jamie Murray will play in both the men’s and mixed doubles at number six, Heather Watson will compete in the women’s doubles, while Neal Skupski and partner Desirae Krawczyk from the USA will also be in action.
Harriet Dart, Lloyd Glasspool, Olivia Nicholls, Maia Lumsden and Luke Johnson are the other Brits on the court in doubles.
